Ken, I believe, according to CuteChat install instructions for DotNetNuke is to add the following to the Global.asax file (root web directory). Here are the contents of our file:
<%@ Application Inherits="DotNetNuke.Common.Global" Language="VB" %>
<script Runat=server>
Public Overrides Sub Init()
MyBase.Init()
If Not CuteChat.ChatSystem.HasStarted Then
CuteChat.ChatProvider.Instance = New DNNChatProvider()
CuteChat.ChatSystem.Start(New CuteChat.AppSystem())
End If
End Sub
</script>