Without using some form of database to maintain and reload the changes.  You might experiment with

Editor1.LoadHTML("document.html") and Editor1.SaveFile("document.html")

Make sure you make backupos your files first.  The optimum solution would be to use a database to store just the content area of the page.  This way the client will not manipulate the layout of the site.  Although Cuteeditor also has templates which might get around this type of issue.